Our research at the Institute of Bioinformatics Research and Education aims at solving fundamental and applied problems in bioinformatics and systems biology, focusing on human genome variation.
Research Group Members
Alexander Predeus, Ph.D.
Yury Barbitoff, Ph.D.
Our team is working in three main directions:
Investigation of the genotype-to-phenotype relationships in human and beyond
The key goal of our research is the identification and in-depth analysis of pleiotropic effects, whereby a single gene affects a variety of traits. We tackle this problem by integrating genome-wide association data and other resources on the phenome scale.
Analysis of the evolutionary aspects of human genome variation.
We are interested in how patterns of within-gene genetic variation reflect functional significance of genomic regions. We utilize large-scale data sources such as the Genome Aggregation Database (gnomAD) to study mechanisms of mutation and selective pressure and develop new tools for annotation of genetic variants.
Application of NGS bioinformatics for medical and population genetics.
We collaborate with several research groups and private genetic laboratories to develop tools for interactive analysis of exome and genome sequencing data.
We are organizing the IBRE Bioinformatics Club, an online meeting of the bioinformatics community devoted to discussing crucial topics in bioinformatics, computational biology, data science, and beyond. Don't miss out. Learn the details and register today!